169 research outputs found

    IP-for-IP or Cash-for-IP? R&D Competition and the Market for Technology

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    This paper argues that firms use 'IP-for-IP' policies such as cross-licensing to strategically restrict transactions in the market for technology. The commitment to limit trade to reciprocal exchange (barter instead of cash transactions) enables firms to alter the allocation of R&D and soften R&D competition. In particular, it induces firms to focus R&D on their area of expertise. The costs of IP-for-IP are foregone gains from trade. Our analysis of the trade-offs involved shows that IP-for-IP is profitable in industries where firms differ in their capabilities to commercialize IP. Patent complementarities and firm asymmetries further strengthen the optimality of IP-for-IP

    IP-for-IP or Cash-for-IP? R&D Competition and the Market for Technology

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    We analyze how firms might benefit from trading restrictions in the market for technology. We show that restricting trade to reciprocal exchange (“IP-for-IP” barter instead of cash transactions), as in cross-licensing agreements, alters the allocation of R&D resources and reduces overinvestment in R&D. The tighter are the trading restrictions, the higher are the costs that are due to forgone gains from trade. Our analysis of the trade-offs involved shows that firms benefit from IP-for-IP restrictions, compared to both free trade and no trade environments, in industries where: (1) firms differ in their capabilities to commercialize IP; and (2) patent complementarities exist

    Effects of Water Saturation and Low Temperature Coupling on the Mechanical Behavior of Carbon and E-Glass Epoxy Laminates

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    An experimentally based study has been conducted to quantify the effects of coupled water saturation and low temperatures on the quasi-static and dynamic mechanical behavior of E-Glass and Carbon Epoxy laminates. The relative performance of the materials as a function of water saturation and decreasing temperature was characterized through detailed experiments, specifically in-plane (tensile/compressive) and shear material properties, static and dynamic Mode-I fracture, and impact/flexure after impact strength. In the investigation temperatures from Room Temperature (20°C) down to arctic seawater and extreme ocean depth conditions (-2°C) were evaluated. The materials utilized in the study, Carbon/Epoxy and E-glass/Epoxy, are chosen due to their primary interest to the underwater vehicle and marine industry communities. The results of the quasi-static and dynamic material experiments show that all properties are affected by both water saturation and decreasing temperature, although the trends are specific to the property under consideration

    Bimodal release ondansetron for acute gastroenteritis among adolescents and adults: A randomized clinical trial

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    Importance: Vomiting resulting from acute gastroenteritis is commonly treated with intravenous antiemetics in acute care settings. If oral treatment were beneficial, patients might not need intravenous administered hydration or medication. Furthermore, a long-acting treatment could provide sustained relief from nausea and vomiting. Objective: To determine whether an experimental long-acting bimodal release ondansetron tablet decreases gastroenteritis-related vomiting and eliminates the need for intravenous therapy for 24 hours after administration. Design, Setting, and Participants: This placebo-controlled, double-blind, randomized clinical trial included patients from 19 emergency departments and 2 urgent care centers in the United States from December 8, 2014, to February 17, 2017. Patients 12 years and older with at least 2 vomiting episodes from presumed gastroenteritis in the previous 4 hours and symptoms with less than 36 hours\u27 duration were randomized using a 3:2 active to placebo ratio. Analyses were performed on an intent-to-treat basis and conducted from June 1, 2017, to November 1, 2017. Intervention: Bimodal release ondansetron tablet containing 6 mg of immediate release ondansetron and 18 mg of a 24-hour release matrix for a total of 24 mg of ondansetron. Main Outcomes and Measures: Treatment success was defined as no further vomiting, no need for rescue medication, and no intravenous hydration for 24 hours after bimodal release ondansetron administration. Results: Analysis included 321 patients (mean [SD] age, 29.0 [11.1] years; 195 [60.7%] women), with 192 patients in the bimodal release ondansetron group and 129 patients in the placebo group. Treatment successes were observed in 126 patients in the bimodal release ondansetron group (65.6%) compared with 70 patients in the placebo group (54.3%), with an 11.4% (95% CI, 0.3%-22.4%) absolute probability difference. The proportion of treatment success was 21% higher among patients who received bimodal release ondansetron compared with those who received a placebo (relative risk, 1.21; 95% CI, 1.00-1.46; P = .04). In an analysis including only patients with a discharge diagnosis of acute gastroenteritis and no major protocol violations, there were 123 treatment successes (69.5%) in the bimodal release ondansetron group compared with 67 treatment successes (54.9%) in the placebo group (relative risk, 1.27; 95% CI, 1.05-1.53; P = .01). Adverse effects were infrequent and similar to the known safety profile of ondansetron. Conclusions and Relevance: This randomized clinical trial found that a long-acting bimodal release oral ondansetron tablet was an effective antiemetic among adolescents and adults with moderate to severe vomiting from acute gastroenteritis. The drug benefits extended to 24 hours after administration. Bimodal release ondansetron may decrease the need for intravenous access and emergency department care to manage acute gastroenteritis. Trial Registration: ClinicalTrials.gov identifier: NCT02246439

    Amount of Time to Eat Lunch Is Associated with Children’s Selection and Consumption of School Meal Entrée, Fruits, Vegetables, and Milk

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    Background There are currently no national standards for school lunch period length and little is known about the association between the amount of time students have to eat and school food selection and consumption. Objective Our aim was to examine plate-waste measurements from students in the control arm of the Modifying Eating and Lifestyles at School study (2011 to 2012 school year) to determine the association between amount of time to eat and school meal selection and consumption. Design We used a prospective study design using up to six repeated measures among students during the school year. Participants/setting One thousand and one students in grades 3 to 8 attending six participating elementary and middle schools in an urban, low-income school district where lunch period lengths varied from 20 to 30 minutes were included. Main outcome measures School food selection and consumption were collected using plate-waste methodology. Statistical analyses performed Logistic regression and mixed-model analysis of variance was used to examine food selection and consumption. Results Compared with meal-component selection when students had at least 25 minutes to eat, students were significantly less likely to select a fruit (44% vs 57%; PPPP Conclusions During the school year, a substantial number of students had insufficient time to eat, which was associated with significantly decreased entrée, milk, and vegetable consumption compared with students who had more time to eat. School policies that encourage lunches with at least 25 minutes of seated time might reduce food waste and improve dietary intake

    Low Temperature Effects on the Mechanical, Fracture, and Dynamic Behavior of Carbon and E-glass Epoxy Laminates

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    An experimental investigation through which the effects of low temperatures on the mechanical, fracture, impact, and dynamic properties of carbon- and E-glass-epoxy composite materials has been conducted. The objective of the study is to quantify the influence of temperatures from 20 °C down to −2 °C on the in-plane (tensile/compressive) and shear material properties, static and dynamic Mode-I fracture characteristics, impact/residual strength, and the storage and loss moduli for the materials considered. The low end of the temperature range considered in the study is associated with Arctic seawater as well as conditions found at extreme ocean depths (2 °C–4 °C). In the investigation, both carbon/epoxy and E-glass/epoxy laminates are evaluated as these materials are of keen interest to the marine and undersea vehicle community. The mechanical characterization of the laminates consists of controlled tension, compression, and short beam shear testing. The Mode-I fracture performance is quantified under both quasi-static and highly dynamic loading rates with additional flexure after impact strength characterization conducted through the use of a drop tower facility. Finally, dynamic mechanical analysis (DMA) testing has been completed on each material to measure the storage and loss moduli of the carbon fiber- and E-glass fiber reinforced composites. The findings of the study show that nearly all characteristics of the mechanical performance of the laminates are both material and temperature dependent

    Collective Sensemaking Around COVID-19: Experiences, Concerns, and Agendas for our Rapidly Changing Organizational Lives

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    Uncertainty is at the forefront of many crises, disasters, and emergencies, and the COVID-19 pandemic is no different in this regard. In this forum, we, as a group of organizational communication scholars currently living in North America, engage in sensemaking and sensegiving around this pandemic to help process and share some of the academic uncertainties and opportunities relevant to organizational scholars. We begin by reflexively making sense of our own experiences with adjusting to new ways of working during the onset of the pandemic, including uncomfortable realizations around privilege, positionality, race, and ethnicity. We then discuss key concerns about how organizations and organizing practices are responding to this extreme uncertainty. Finally, we offer thoughts on the future of work and organizing informed by COVID-19, along with a list of research practice considerations and potentially generative research questions. Thus, this forum invites you to reflect on your own experiences and suggests future directions for research amidst and after a cosmology event

    Critical international relations and the impact agenda

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    How should critical International Relations (IR) scholars approach the ‘impact agenda’? While most have been quite resistant to it, I argue in this essay that critical IR should instead embrace the challenge of impact – and that both IR as a field and the impact agenda more broadly would gain greatly from it doing so. I make this case through three steps. I show, firstly, that critical IR has till now been very much at the impact agenda’s margins, and that this situation contrasts strikingly with its well-established importance within IR teaching and research. I argue, secondly, that critical IR scholars both could and should do more impact work – that the current political conjuncture demands it, that many of the standard objections to doing so are misplaced, and indeed that ‘critical’ modes of research are in some regards better suited than ‘problem-solving’ ones to generating meaningful change – and offer a series of recommended principles for undertaking critically-oriented impact and engagement work. But I also argue, thirdly, that critical social science holds important lessons for the impact agenda, and that future impact assessments need to take these lessons on board – especially if critical IR scholarship is to embrace impact more fully. Critical IR, I submit, should embrace impact; but at the same time, research councils and assessments could do with modifying their approach to it, including by embracing a more critical and political understanding of what impact is and how it is achieved
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